Preheat your oven to 325 degrees F. Spray your 9-inch by 13-inch cake pan with non-stick cooking spray, line the bottom with parchment and spray again. Set aside.
Place the Biscoff cookies in a food processor or blender and pulse until the cookies are finely ground and resemble sand.
In a medium-size bowl, combine the Biscoff crumbs, all-purpose flour, baking powder, baking soda, and salt. Whisk until the ingredients are well-blended. Set aside.
In the bowl of a stand mixer fitted the paddle attachment, beat the butter, brown sugar and granulated sugar on medium speed until light and fluffy. Add the eggs, one at a time, beating well after each addition.
Before adding the dry ingredients, continue to beat the wet ingredients for about 1 to 2 minutes on medium-high speed, until the mixture is smooth.
With the mixer on low speed, add 1/3 of the dry ingredients and mix until combined. Slowly add half of the buttermilk and mix until incorporated. Continue alternating the flour and buttermilk until it has all been incorporated. Scrape down the sides of the bowl and slowly mix for another 20-30 seconds.
Pour the batter into the prepared pan. Bake for 35 to 40 minutes. Cool 15 to 20 minutes on a wire rack before inverting onto a cooling rack to cool completely.